Dementia is the clinical expression of a multitude of pathological aberrations in the Central nervous System (CNS). The most common pathological substrate in demented elderly is Alzheimer’s disease. This CNS disorder is affecting more than 5 million Americans, and 18 million patients worldwide. Current medications provide limited and symptomatic relieve. There is a huge unmet medical need for disease-modifying treatments that will slow or revert the pathological cascades leading to neurodegeneration.